Long-lasting high molecular weight non cross-linked hyaluronic acid biorevitalising mesotherapy



Long-lasting high molecular weight non cross-linked hyaluronic acid biorevitalising mesotherapy.

A new concept in biorevitalisation with triple action

The skin undergoes changes over time. To prevent premature ageing, injections of non cross-linked hyaluronic acid compensate for the natural loss of this substance while providing many other benefits. Discover a new concept in biorevitalisation with triple action:

  • Strengthens the skin’s protective barrier

  • Revitalises skin so it looks and feels softer, smoother and radiantly hydrated

  • Rehydrates: hydro-balance restoration



Non cross-linked hyaluronic acid

  • HA quantity: 13.5 mg / syringe

  • Concentration: 9 mg/ml

  • Syringe: 1.5ml

  • Very high molecular weight: 3,000 kDa due to Hyasep® technology

  • Injectable certification – Medical product

Simulation made with a computer program. Results do not correspond to those obtained from a real treatment.


Your skin needs revitalising treatments to recover its glow, hydration and elasticity and to prevent further signs of ageing.

May be used on any part of the body that requires biorevitalisation, except the breasts.

Hyaluronic acid of the skin

Hyaluronic acid is a molecule found naturally in the skin. Its natural form is a chain of sugars based on repetitions that form a net in which the different chains are intertwined. Its molecular weight ranges between 2,500-3,500 kDa.

TKN HA 3 is a hyaluronic acid with a molecular weight of 3,000 kDa. Same molecular weight as the physiological hyaluronic acid found in the dermis: 3,000 kDa[5].

Our innovation

Conservation of the molecular weight and its characteristics throughout the manufacturing process

HYAsep® Technology

This technology maintains sterility throught the manufacturing process, helping to preserve a high molecular weight.

HYAsep® technology

Injectable biorevitalisers must be sterile products

The most common process used to sterilise hyaluronic acid is end point sterilisation by autoclave, which usually reduces its molecular weight by about half[4].

  • HYAsep® technology quantifies and controls all stages and materials of the manufacturing process to ensure that they are all capable of producing a sterile product without the need of an end point sterilisation.
  • The final container also meets sterile conditions before being filled.
  • The result is a hyaluronic acid that maintains all its high-quality and very high Molecular Weight characteristics from start to finish.

TOSKANIMED offers an innovative alternative in the field of biorevitalisers: non cross-linked hyaluronic acid.

Very high molecular weight

TKN HA 3 3000kDa
Other biorevitalisers ~ 1700kDa

Application Techniques

Application Area

Clinically tested results[10]


notice brighter, more radiant skin


notice younger skin


have received positive remarks about the quality of their skin by others


want to continue with this treatment long-term


  • Injection in the eyelids. Application of the product beneath the eyes should only be carried out by specialists specifically trained in this technique with deep knowledge of the physiology of the area

  • Injection in the epidermis

  • Patients with known sensitivity to any of the product’s ingredients

  • Patients suffering from acute or chronic inflammation or infection in the area being treated

  • Patients prone to developing inflammatory skin conditions or hypertrophic scarring

  • Patients with poor or unhealthy tissue vascularisation or systematic disorders that affect healing

  • Patients with poor or unhealthy tissue vascularisation or systematic disorders that affect healing

  • Patients with history of anaphylactic reaction

  • Patients treated with aspirin or any drug that may affect the healing process

  • Use in areas containing foreign bodies (for example, silicone, other particular materials)

  • Use in an area with an inflammatory and/or skin process (acne, herpes, etc.)

  • Simultaneous use with laser treatments, deep chemical peels or dermabrasion. For superficial peels, we do not recommend injecting the product if it causes a considerable inflammatory reaction

  • Patients with autoimmune diseases

  • Patients with porphyria

  • Patients with untreated epilepsy

  • Pregnant or breastfeeding women

  • Patients under 18 years old

4. O’Connell CD, Onofrillo C, Duchi S, Li X, Zhang Y, Tian P, Lu L, Trengove A, Quigley A, Gambhir S, Khansari A, Mladenovska T, O’Connor A, Di Bella C, Choong PF, Wallace GG. Evaluation of sterilisation methods for bio-ink components: gelatin, gelatin methacryloyl, hyaluronic acid and hyaluronic acid methacryloyl. Biofabrication. 2019 Apr 3;11(3):035003. doi: 10.1088/1758-5090/ab0b7c. PMID: 30818298.
5. Asseptic media fill process.
10. Results obtained after 4 sessions carried out every 3 weeks using a syringe per session.

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Passatge Ciutadans, 4, 08005 Barcelona
Ph. +34 938 447 825 |

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