Long-lasting high molecular weight non cross-linked hyaluronic acid biorevitalising mesotherapy
Discover a new concept in biorevitalisation with a triple action:
Long-lasting high molecular weight non cross-linked hyaluronic acid biorevitalising mesotherapy
Very high molecular weight
Thanks to HYAsep® technology, we obtain a larger molecule that degrades much more slowly and therefore has a longer-lasting effect.
The amount of water retained is greater, thus providing more plumpness.
Same molecular weight as that found naturally in the dermis: 3,000 kDa.
This technology maintains sterility throught the manufacturing process, helping to preserve a high molecular weight.
Injectable biorevitalisers must be sterile products
The most common process used to sterilise hyaluronic acid is end point sterilisation by autoclave, which usually reduces its molecular weight by about half[4].
HYAsep® technology quantifies and controls all stages and materials of the manufacturing process to ensure that they are all capable of producing a sterile product without the need of an end point sterilisation.
The final container also meets sterile conditions before being filled.
The result is a hyaluronic acid that maintains all its high-quality and very high Molecular Weight characteristics from start to finish.
TKN HA 3 allows treatments commonly used in aesthetic medicine, to be combined to achieve maximum skin quality.
Can be combined in the same session or alternated between sessions.
A larger molecule degrades much more slowly due to its smaller contact surface[8]. Due to the smaller contact surface of the HA with the medium, the hyaluronidases have fewer binding sites and degrade the hyaluronic acid much more slowly.
References
4. O’Connell CD, Onofrillo C, Duchi S, Li X, Zhang Y, Tian P, Lu L, Trengove A, Quigley A, Gambhir S, Khansari A, Mladenovska T, O’Connor A, Di Bella C, Choong PF, Wallace GG. Evaluation of sterilisation methods for bio-ink components: gelatin, gelatin methacryloyl, hyaluronic acid and hyaluronic acid methacryloyl. Biofabrication. 2019 Apr 3;11(3):035003. doi: 10.1088/1758-5090/ab0b7c. PMID: 30818298.
5. Asseptic media fill process
8. Increasing the contact Surface between reagents (ground or dissolved substances) increases the reaction rate
9. Market research carried out by TOSKANI
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